ChloroquineV1, Main, Exploration, bibRecord, 000779

High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses

Identifieur interne : 000779 ( Main/Exploration ); précédent : 000778; suivant : 000780

High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses

Source :

Journal of Virology [ 0022-538X ] ; 2019.

RBID : PMC:6613765

Abstract

Currently, there is no approved therapy to treat coronavirus infection; therefore, broad-spectrum inhibitors of emerging and endemic CoVs are needed. Based on our high-throughput screening assay using a compound library, we identified seven compounds with broad-spectrum efficacy against the replication of four CoVs in vitro. Additionally, one compound (lycorine) was found to protect BALB/c mice against HCoV-OC43-induced lethality by decreasing viral load in the central nervous system. This inhibitor might offer promising therapeutic possibilities for combatting novel CoV infections in the future.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613765

DOI: 10.1128/JVI.00023-19
PubMed: 30918074
PubMed Central: 6613765

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Currently, there is no approved therapy to treat coronavirus infection; therefore, broad-spectrum inhibitors of emerging and endemic CoVs are needed. Based on our high-throughput screening assay using a compound library, we identified seven compounds with broad-spectrum efficacy against the replication of four CoVs <italic>in vitro</italic>
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High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses

High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses

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Abstract

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